Transmural dispersion in LQT and arrhythmogenesis
نویسندگان
چکیده
منابع مشابه
Transmural dispersion in LQT3 and arrhythmogenesis
We thank Dr. Opthof and Dr. Coronel for the interest in our recently published work [1] and appreciate their comments. We aimed at developing a novel intact heart model of LQT3 for a better understanding of the mechanisms by which functional electrical instability at the level of the whole heart leads to torsade de pointes (TdP). The potassium concentration was repeatedly lowered to design an e...
متن کاملTransmural dispersion in LQT3 and arrhythmogenesis.
At the end of the 19th century Einthoven described the configuration of the human ECG [1] and in later papers he elaborated on the magnitude and direction of its components [2]. From an intellectual point of view it is in fact unacceptable that we still do not know exactly how the T wave emerges. More precisely, we may understand how (dispersion in) repolarization within the ventricles transfor...
متن کاملTransmural electrophysiological heterogeneities underlying arrhythmogenesis in heart failure.
Although expression of numerous ion channels is altered in heart failure (HF), mechanisms by which dysfunction at the ionic and molecular levels lead to ventricular tachyarrhythmias in HF are unknown. Previously, we found that transmural heterogeneities of repolarization play a critical role in the genesis of polymorphic ventricular tachycardia (PVT) when QT interval was prolonged in LQT2. Beca...
متن کاملAmplified transmural dispersion of repolarization as the basis for arrhythmogenesis in a canine ventricular-wedge model of short-QT syndrome.
BACKGROUND The short-QT syndrome is a new clinical entity characterized by corrected QT intervals <300 ms and a high incidence of ventricular tachycardia (VT) and fibrillation (VF). Gain-of-function mutations in the gene for outward potassium currents have been shown to underlie the congenital syndrome. The present study examined the cellular basis of VT/VF in an experimental model associated w...
متن کاملTransmural dispersion of repolarization in failing and nonfailing human ventricle.
RATIONALE Transmural dispersion of repolarization has been shown to play a role in the genesis of ventricular tachycardia and fibrillation in different animal models of heart failure (HF). Heterogeneous changes of repolarization within the midmyocardial population of ventricular cells have been considered an important contributor to the HF phenotype. However, there is limited electrophysiologic...
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ژورنال
عنوان ژورنال: Cardiovascular Research
سال: 2005
ISSN: 0008-6363
DOI: 10.1016/j.cardiores.2005.07.008